Nano Technology Platform
LEVERAGING TINY SIZES FOR TOWERING PERFORMANCE
Nanotechnology is branch of science that deals with dimensions of less than 100 nanometers. As it relates to materials science, applied to the healthcare domain, it has potential to greatly impact Drug Delivery, Imaging & Diagnostics, Tumor Targeting, and Therapeutics.
1. Nano ablation
Current cancer therapies include radiation, chemotherapy, surgery, and immunotherapy, where each alone or in combination have varying efficacy, toxicity, and cost. There remains the need for a highly efficacious therapeutic with limited toxicity at reduced cost. AccuDx’s nanodisc technology addresses this need.
Introduction
Current cancer therapies include radiation, chemotherapy, surgery, and immunotherapy, where each alone or in combination have varying efficacy, toxicity, and cost. There remains the need for a highly efficacious therapeutic with limited toxicity at reduced cost. AccuDx’s nanodisc technology addresses this need.
Biodegradable, ferromagnetic nanodiscs (BMND) conjugated to antibodies that enable cancer cell targeting is expected to be administered to a patient.
When a low magnetic force is applied from outside of body, it induces oscillation of the nanodiscs (BMND). The mechanical force of oscillation is transduced to the membrane to achieve cancer cell destruction and apoptosis.
Current status
Lab scale manufacturing process as well as safety and efficacy studies are completed. In vitro lab studies on Leukemia and tumor mouse/rat model are completed that serve as a foundation for pre-clinical studies.
IP Details
Publication number: 20220040303
Filed: November 1, 2019
Publication date: February 10, 2022
Inventors: Raveendran POTTATHIL, Sanjay DESHMUKH, Kiran KHARAT
2. Nano Kidney
We have developed a novel, nano-conjugate based cartridge for blood urea reduction. As a next step, other removable components from blood such as potassium and excess water will be dealt with using a similar strategy. By incorporating tandem cartridges for the removal of urea, potassium, creatine and water in a single treatment session, Accudx’s nano kidney will improve the quality of life of patients with chronic kidney disease..
Introduction,
Current status
Proof of concept stage work is completed. We screened and identified nano structures that are capable of effectively removing urea from blood both in vitro and in vivo. Prototype cartridges were built. The effectiveness was demonstrated in canine and rabbit animal models. The integrity of active components of cartridges were tested for flow characteristics and leaching with satisfactory results. Active components were also tested for cellular toxicity.
IP Details
- Patent Application Publication (21) Application No.202021029811 A / Publication Date : 31/07/2020
Inventors: Raveendran POTTATHIL, Sanjay DESHMUKH, Kiran KHARAT